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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 560496생성일: 2026년 10월 25일

4-Methyl-3-(trifluoromethyl)benzoic acid → 4-Methyl-N-[(1S,2S,5R)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-3-trifluoromethyl-benzamide

https://huagongshe.com/reaction/560496

반응식

참여 물질

역할이름HCID투입량
반응물4-Methyl-3-(trifluoromethyl)benzoic acidHCID 2775592—
반응물((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanoneHCID 66998654—
생성물4-Methyl-N-[(1S,2S,5R)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-3-trifluoromethyl-benzamideHCID 66998783—

반응 단계

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 4-Methyl-3-trifluoromethyl-benzoic acid. LC-MS (basic): tR=1.00 min; [M+H]+=514.1.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08063099B2
출처 데이터셋uspto-grants-2011_11
ORD IDord-51b68cfb8a84454e86779f7d31a818fa
출처 메모uspto-grants-2011_11