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HRID 560510作成日：2026年10月25日

4-Methoxy-3-(trifluoromethyl)benzoic acid → 4-Methoxy-N-[(1S,2S,5R)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-3-trifluoromethyl-benzamide

https://huagongshe.com/reaction/560510

反応式

関与物質

役割名称HCID仕込み量
反応物4-Methoxy-3-(trifluoromethyl)benzoic acidHCID 2775295—
反応物((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanoneHCID 66998654—
生成物4-Methoxy-N-[(1S,2S,5R)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-3-trifluoromethyl-benzamideHCID 66998626—

反応手順

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 4-Methoxy-3-trifluoromethyl-benzoic acid. LC-MS (basic): tR=0.96 min; [M+H]+=530.0.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08063099B2
出典データセットuspto-grants-2011_11
ORD IDord-d50217b884ac468d91db249e815fc1d2
出典メモuspto-grants-2011_11