2-Methylimidazo(2,1-b)(1,3)thiazole-5-carboxylic acid → 2-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1s,2s,5r)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

HRID 560516Notes

Reaction equation

HRID 560516 reaction equation
[NH2:1][CH2:2][C@H:3]1[N:8]([C:9]([C:11]2[N:12]=[C:13]([CH3:23])[S:14][C:15]=2[C:16]2[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=2)=[O:10])[CH2:7][C@H:6]2[C@@H:4]1[CH2:5]2.[CH3:24][C:25]1[S:29][C:28]2=[N:30][CH:31]=[C:32]([C:33](O)=[O:34])[N:27]2[CH:26]=1>>[CH3:23][C:13]1[S:14][C:15]([C:16]2[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=2)=[C:11]([C:9]([N:8]2[CH2:7][C@H:6]3[C@H:4]([CH2:5]3)[C@H:3]2[CH2:2][NH:1][C:33]([C:32]2[N:27]3[C:28]([S:29][C:25]([CH3:24])=[CH:26]3)=[N:30][CH:31]=2)=[O:34])=[O:10])[N:12]=1

Participants

3

Reactant 2

HCID 574371412-Methylimidazo(2,1-b)(1,3)thiazole-5-carboxylic acidHCID 66998654((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

Product 1

HCID 669977932-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1s,2s,5r)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Procedure

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid. LC-MS (basic): tR=0.86 min; [M+H]+=491.9.

Sources & evidence

ORD record
ord-e002ec49102c4dca909671682370d95b
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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