6-(Trifluoromethyl)imidazo[2,1-b][1,3]thiazole-5-carboxylic acid → HCID 66998840, compound

HRID 560517Notes

Reaction equation

HRID 560517 reaction equation
[NH2:1][CH2:2][C@H:3]1[N:8]([C:9]([C:11]2[N:12]=[C:13]([CH3:23])[S:14][C:15]=2[C:16]2[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=2)=[O:10])[CH2:7][C@H:6]2[C@@H:4]1[CH2:5]2.[F:24][C:25]([F:38])([F:37])[C:26]1[N:27]=[C:28]2[N:32]([C:33]=1[C:34](O)=[O:35])[CH:31]=[CH:30][S:29]2>>[CH3:23][C:13]1[S:14][C:15]([C:16]2[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=2)=[C:11]([C:9]([N:8]2[CH2:7][C@H:6]3[C@H:4]([CH2:5]3)[C@H:3]2[CH2:2][NH:1][C:34]([C:33]2[N:32]3[C:28]([S:29][CH:30]=[CH:31]3)=[N:27][C:26]=2[C:25]([F:37])([F:24])[F:38])=[O:35])=[O:10])[N:12]=1

Participants

3

Reactant 2

HCID 574371426-(Trifluoromethyl)imidazo[2,1-b][1,3]thiazole-5-carboxylic acidHCID 66998654((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

Product 1

HCID 66998840HCID 66998840, compound

Procedure

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 6-Trifluoromethyl-imidazo[2,1-b]thiazole-5-carboxylic acid. LC-MS (basic): tR=0.92 min; [M+H]+=545.9.

Sources & evidence

ORD record
ord-b4ffb67bc00f4765b86e8177ea485d6b
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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