3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid → HCID 66998295, compound

HRID 560522Notes

Reaction equation

HRID 560522 reaction equation
[NH2:1][CH2:2][C@H:3]1[N:8]([C:9]([C:11]2[N:12]=[C:13]([CH3:23])[S:14][C:15]=2[C:16]2[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=2)=[O:10])[CH2:7][C@H:6]2[C@@H:4]1[CH2:5]2.[O:24]=[C:25]1[NH:30][C:29]2[CH:31]=[CH:32][CH:33]=[C:34]([C:35](O)=[O:36])[C:28]=2[O:27][CH2:26]1>>[CH3:23][C:13]1[S:14][C:15]([C:16]2[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=2)=[C:11]([C:9]([N:8]2[CH2:7][C@H:6]3[C@H:4]([CH2:5]3)[C@H:3]2[CH2:2][NH:1][C:35]([C:34]2[C:28]3[O:27][CH2:26][C:25](=[O:24])[NH:30][C:29]=3[CH:31]=[CH:32][CH:33]=2)=[O:36])=[O:10])[N:12]=1

Participants

3

Reactant 2

HCID 183549413-Oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acidHCID 66998654((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

Product 1

HCID 66998295HCID 66998295, compound

Procedure

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid. LC-MS (basic): tR=0.77 min; [M+H]+=503.0.

Sources & evidence

ORD record
ord-727a9e1ac0e648639a4aa1f5b838b72e
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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