HCID 66998520, compound → HCID 66998498, compound

HRID 560532Notes

Reaction equation

HRID 560532 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:29]2[CH:30]=[C:31]([CH3:35])[CH:32]=[CH:33][CH:34]=2)=[C:5]([C:7]([N:9]2[CH2:14][C@H:13]3[C@H:11]([CH2:12]3)[C@H:10]2[CH2:15][NH:16][C:17]([C:19]2[CH:20]=[CH:21][CH:22]=[C:23]3[S:27][C:26](Cl)=[N:25][C:24]=23)=[O:18])=[O:8])[N:6]=1>CO.[Pd]>[CH3:1][C:2]1[S:3][C:4]([C:29]2[CH:30]=[C:31]([CH3:35])[CH:32]=[CH:33][CH:34]=2)=[C:5]([C:7]([N:9]2[CH2:14][C@H:13]3[C@H:11]([CH2:12]3)[C@H:10]2[CH2:15][NH:16][C:17]([C:19]2[CH:20]=[CH:21][CH:22]=[C:23]3[S:27][CH:26]=[N:25][C:24]=23)=[O:18])=[O:8])[N:6]=1

Participants

4

Reactant 1

HCID 66998520HCID 66998520, compound

Product 1

HCID 66998498HCID 66998498, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 2-Chloro-benzothiazole-4-carboxylic acid[(1S,2S,5R)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide (0.04 mmol) in MeOH (2.0 mL) is treated with Pd/C (10%, 50 mg) and stirred under a hydrogen atmosphere (1 bar) for 3 h. After filtration through celite and removal of the solvents the desired product is obtained. LC-MS: tR=0.98 min; [M+H]+=489.1.

Workup

  1. filtrationAfter filtration
  2. customthrough celite and removal of the solvents the desired product
  3. customis obtained

Sources & evidence

ORD record
ord-cfb189fd06a64052a3955484b2836e57
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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