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4-Fluoroaniline → N-(2,2-dimethoxyethyl)-N-(4-fluorobenzyl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluoroaniline | HCID 9731 | — |
| 反応物 | 4-Fluorobenzylamine | HCID 67326 | — |
| 反応物 | Acetaldehyde, 2,2-dimethoxy- | HCID 162650 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 生成物 | N-(2,2-dimethoxyethyl)-N-(4-fluorobenzyl)amine | HCID 11615438 | 71% |
反応手順
Following the procedure as described in step A of Preparation 2, making variations as required to replace 4-fluoroaniline with 4-fluorobenzylamine to react with dimethoxyacetaldehyde followed by the imine reduction with sodium triacetoxyborohydride, N-(4-fluorobenzyl)-2,2-dimethoxyethanamine was obtained in 71% yield: 1H NMR (300 MHz, CDCl3) δ 7.24-7.19 (m, 2H), 6.97-6.89 (m, 2H), 4.43-4.39 (m, 1H), 3.70 (s, 2H), 3.30 (s, 6H), 2.67 (dd, J=5.4, 1.5 Hz, 2H); MS (ES+) m/z 214.3 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063084B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-a442cedb30bf4d6c8098e4c4b8036e5f |
| 出典メモ | uspto-grants-2011_11 |