HCID 118071560, compound → (E)-N-[2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-(isopropoxyimino)ethyl]-2-(trifluoromethyl)benzamide

HRID 56054Notes

Reaction equation

[Cl:1][C:2]1[C:3](/[C:12](=[N:27]/[O:28][CH:29]([CH3:31])[CH3:30])/[CH2:13][NH:14][C:15](=[O:26])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]([F:25])([F:24])[F:23])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1>C(O)(=O)C>[Cl:1][C:2]1[C:3](/[C:12](=[N:27]\[O:28][CH:29]([CH3:31])[CH3:30])/[CH2:13][NH:14][C:15](=[O:26])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]([F:24])([F:25])[F:23])=[N:4][CH:5]=[C:6]([C:8]([F:9])([F:11])[F:10])[CH:7]=1

Participants

Conditions

Temperature: 70 °C

Procedure

11.00 g of (E)-N-[2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-(isopropoxyimino)ethyl]-2-(trifluoromethyl)benzamide was dissolved in 30 ml of acetic acid and stirred at 70° C. for 1 hour. After completion of the reaction, the solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using ethyl acetate-chloroform (with a gradient of from 0:100 to 5:95) as the eluent to obtain 5.63 g of the desired product as white crystals.

Workup

customAfter completion of the reaction
customthe solvent was evaporated under reduced pressure
customthe resulting residue was purified by silica gel column chromatography

Sources & evidence

ORD record: ord-4fdddbf231b641549e0d1d74edb4b36e
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09434684B2

Reaction notes

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