Benzylamine → 2-Bromo-N-(3,4-difluorobenzyl)-4-methylthiazole-5-carboxamide

Participants

Reaction Steps

Following the procedure as described in Preparation 8, making variations as required to replace benzyl amine with (3,4-difluorophenyl)methanamine to react with 2-bromo-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a colorless solid in 61% yield: 1H NMR (300 MHz, CDCl3) δ 7.16-7.01 (m, 3H), 6.08-5.94 (m, 1H), 4.52 (d, J=5.9 Hz, 2H), 2.64 (s, 3H); MS (ES+) m/z 347.2 (M+1), 349.2 (M+3).

Provenance & Evidence