Benzyl Bromide → 1-(4-Methylthiazol-2-yl)-3-(4-(trifluoromethyl)benzyl)imidazolidin-2-one

Participants

Reaction Steps

Following the procedure as described in Example 5, making variations to replace benzyl bromide with 4-(trifluoromethyl)benzyl bromide to react with 1-(4-methylthiazol-2-yl)imidazolidin-2-one, the title compound was obtained in 42% yield: mp 102-103° C. (ethyl acetate/hexanes); 1H NMR (300 MHz, CDCl3) δ 7.58 (d, J=8.1 Hz, 2H), 7.39 (d, J=8.1 Hz, 2H), 6.42 (s, 1H), 4.51 (s, 2H), 4.10-4.04 (m, 2H), 3.45-3.39 (m, 2H), 2.29 (s, 3H); MS (ES+) m/z 342.2 (M+1).

Provenance & Evidence