Ethyl 2-(3-(2-cyclopropylethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate → 2-(3-(2-Cyclopropylethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid

Participants

Reaction Steps

Following the procedure as described in Example 6, making variations as required to replace ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate with ethyl 2-(3-(2-cyclopropylethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate, the title compound was obtained in 88% yield: 1H NMR (300 MHz, DMSO-d6) δ 4.20-3.04 (m, 6H), 2.45 (s, 3H), 1.50-1.41 (m, 2H), 0.78-0.54 (m, 1H), 0.43-0.28 (m, 2H), 0.10-0.96 (m, 2H); MS (ES+) m/z 296.2 (M+1).

Provenance & Evidence