Ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate → 4-Methyl-2-(2-oxo-3-phenethylimidazolidin-1-yl)thiazole-5-carboxylic acid

Participants

Reaction Steps

Following the procedure as described in Example 5, making variations as required to replace ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate with ethyl 4-methyl-2-(2-oxo-3-phenethylimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained in 92% yield: 1H NMR (300 MHz, DMSO-d6) δ 7.29-7.14 (m, 5H), 3.92 (t, J=7.2 Hz, 2H), 3.53-3.41 (m, 4H), 2.79 (t, J=7.8 Hz, 2H), 2.46 (s, 3H); MS (ES+) m/z 332.2 (M+1).

Provenance & Evidence