Ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate → HCID 178448532, compound

HRID 560611Notes

Reaction equation

HRID 560611 reaction equation
C[C:2]1[N:3]=[C:4]([N:12]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][CH:20]=CC=3)[C:13]2=[O:23])[S:5][C:6]=1[C:7]([O:9]CC)=[O:8].[CH2:24](N1CCN(C2SC(C(OCC)=O)=C(C)N=2)C1=O)CCC>>[CH2:17]([N:14]1[CH2:15][CH2:16][N:12]([C:4]2[SH:5]([CH3:24])[C:6]([C:7]([OH:9])=[O:8])=[CH:2][N:3]=2)[C:13]1=[O:23])[CH2:22][CH2:21][CH3:20]

Participants

3

Reactant 2

HCID 58031446Ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylateHCID 58031484HCID 58031484, compound

Product 1

HCID 178448532HCID 178448532, compoundYield 94%

Procedure

Following the procedure as described in Example 6, making variations as required to replace ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate with ethyl 2-(3-butyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate, the title compound was obtained in 94% yield: MS (ES+) m/z 284.2 (M+1).

Sources & evidence

ORD record
ord-870a8e1a9e5141b7978a32f63879770f
Source dataset
uspto-grants-2011_11
Patent number
US08063084B2

Reaction notes

Loading…