Ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate → 4-((3-(5-Acetyl-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoic acid

Participants

Reaction Steps

Following the procedure as described in Example 6, making variations as required to replace ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate with methyl 4-((3-(5-acetyl-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoate, the title compound was obtained in 85% yield: 1H NMR (300 MHz, DMSO-d6) δ 12.89 (br s, 1H), 7.90 (d, J=7.5 Hz, 2H), 7.39 (d, J=7.5 Hz, 2H), 4.49 (s, 2H), 4.05-3.90 (m, 2H), 3.52-3.40 (m, 2H), 2.51 (s, 3H), 2.42 (s, 3H); MS (ES+) m/z 360.1 (M+1).

Provenance & Evidence