2-(Pyridin-3-yl)ethan-1-amine → HCID 59481248, compound

Participants

Reaction Steps

Following the procedure as describe in Example 9, making variations as required to replace 2-(3-benzyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid with 4-methyl-2-(2-oxo-3-(4-(trifluoromethoxy)benzyl)imidazolidin-1-yl)thiazole-5-carboxylic acid to react with 3-(2-aminoethyl)pyridine, the title compound was obtained as a white powder in 21% yield: mp 172-173° C. (ethyl acetate/hexanes); 1H NMR (300 MHz, CDCl3) δ 8.46 (s, 2H), 7.53 (d, J=7.8 Hz, 1H), 7.35-7.16 (m, 5H), 5.81 (br s, 1H), 4.46 (s, 2H), 4.08-4.03 (m, 2H), 3.65-3.59 (m, 2H), 3.47-3.42 (m, 2H), 2.92-2.87 (m, 2H), 2.53 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 162.6, 157.2, 155.4, 152.8, 150.1, 148.9, 148.1, 136.2, 134.3, 134.2, 129.6, 123.5, 121.4, 117.5, 47.2, 42.0, 41.8, 40.9, 33.0, 17.1; MS (ES+) m/z 506.4 (M+1).

Provenance & Evidence