1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 58031452, compound

HRID 560697Notes

Reaction equation

HRID 560697 reaction equation
FC(F)(F)C1C=CC(CBr)=CC=1.Br[CH2:14][C:15]1[N:16]=[CH:17][O:18][C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[CH3:26][C:27]1[N:28]=[C:29]([N:37]2[CH2:41][CH2:40][NH:39][C:38]2=[O:42])[S:30][C:31]=1[C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[CH3:26][C:27]1[N:28]=[C:29]([N:37]2[CH2:41][CH2:40][N:39]([CH2:14][C:15]3[N:16]=[CH:17][O:18][C:19]=3[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:38]2=[O:42])[S:30][C:31]=1[C:32]([O:34][CH2:35][CH3:36])=[O:33]

Participants

4

Reactant 3

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 27763014-(Bromomethyl)-5-phenyloxazoleHCID 57919776Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate

Product 1

HCID 58031452HCID 58031452, compoundYield 81%

Procedure

Following the procedure as described in Example 13, making variations as required to replace 4-(trifluoromethyl)benzyl bromide with 4-(bromomethyl)-5-phenyloxazole to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained as a colorless solid in 81% yield: MS (ES+) m/z 413.1 (M+1).

Sources & evidence

ORD record
ord-49f431bfab2c42a6bd64def2ffebe6db
Source dataset
uspto-grants-2011_11
Patent number
US08063084B2

Reaction notes

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