Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Bromomethyl)-4-(trifluoromethyl)benzene → Ethyl 4-methyl-2-(2-oxo-3-(pyridin-2-ylmethyl) imidazolidin-1-yl)thiazole-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Bromomethyl)-4-(trifluoromethyl)benzene | HCID 123062 | — |
| 반응물 | 2-(Bromomethyl)pyridine hydrochloride | HCID 21985098 | — |
| 반응물 | Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate | HCID 57919776 | — |
| 생성물 | Ethyl 4-methyl-2-(2-oxo-3-(pyridin-2-ylmethyl) imidazolidin-1-yl)thiazole-5-carboxylate | HCID 58031467 | 55% |
반응 단계
Following the procedure as described in Example 13, making variations as required to replace 4-(trifluoromethyl)benzyl bromide with 2-(bromomethyl)pyridine hydrochloride to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained as a colorless solid in 55% yield: MS (ES+) m/z 347.2 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063084B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-1f184ee19d3f42aa8f5e0ed3dd5e661d |
| 출처 메모 | uspto-grants-2011_11 |