1-(Bromomethyl)-4-(trifluoromethyl)benzene → Ethyl 4-methyl-2-(2-oxo-3-(pyridin-2-ylmethyl) imidazolidin-1-yl)thiazole-5-carboxylate

HRID 560702Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 560702
FC(F)(F)[C:3]1[CH:10]=[CH:9][C:6](CBr)=[CH:5][CH:4]=1.Cl.BrCC1C=[N:18]C=CC=1.[CH3:22][C:23]1[N:24]=[C:25]([N:33]2[CH2:37][CH2:36][NH:35][C:34]2=[O:38])[S:26][C:27]=1[C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[CH3:22][C:23]1[N:24]=[C:25]([N:33]2[CH2:37][CH2:36][N:35]([CH2:3][C:10]3[CH:9]=[CH:6][CH:5]=[CH:4][N:18]=3)[C:34]2=[O:38])[S:26][C:27]=1[C:28]([O:30][CH2:31][CH3:32])=[O:29]

Komponenten

4

Edukt 3

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 226414833-Bromomethylpyridine hydrochlorideHCID 57919776Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate

Produkt 1

HCID 58031467Ethyl 4-methyl-2-(2-oxo-3-(pyridin-2-ylmethyl) imidazolidin-1-yl)thiazole-5-carboxylateAusbeute 68 %

Versuchsvorschrift

Following the procedure as described in Example 13, making variations as required to replace 4-(trifluoromethyl)benzyl bromide with 3-(bromomethyl)pyridine hydrochloride to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained as a colorless solid in 68% yield: MS (ES+) m/z 347.1 (M+1).

Quellen und Nachweise

ORD-Eintrag
ord-19265f50fcd94efc870284d6af3870c0
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063084B2

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