Ethyl 3-methyl-5-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)thiophene-2-carboxylate → 5-(3-(4-Fluorobenzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylic acid

Participants

Reaction Steps

Following the procedure as described in Example 14, making variations as required to replace ethyl 3-methyl-5-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)thiophene-2-carboxylate with ethyl 5-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylate, the title compound was obtained as a colorless solid in 90% yield: 1H NMR (300 MHz, DMSO-d6) δ 12.34 (br s, 1H), 7.35 (dd, J=8.6, 5.6 Hz, 2H), 7.19 (t, J=8.6 Hz, 2H), 6.29 (s, 1H), 4.39 (s, 2H), 3.87-3.78 (m, 2 H), 3.48-3.40 (m, 2H), 2.40 (s, 3H); MS (ES+) m/z 335.2 (M+1).

Provenance & Evidence