Ethyl 3-methyl-5-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)thiophene-2-carboxylate → 4-Methyl-2-(3-((3-methyl-5-phenylisoxazol-4-yl)methyl)-2-oxoimidazolidin-1-yl)thiazole-5-carboxylic acid

Participants

Reaction Steps

Following the procedure as described in Example 14, making variations as required to replace ethyl 3-methyl-5-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)thiophene-2-carboxylate with ethyl 4-methyl-2-(3-((3-methyl-5-phenylisoxazol-4-yl)methyl)-2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained as a colorless solid in 88% yield: 1H NMR (300 MHz, DMSO-d6) δ 7.64-7.61 (m, 2H), 7.49-7.47 (m, 3H), 4.40 (s, 2H), 3.87-3.82 (m, 2H), 3.28-3.23 (m, 2H), 2.48 (s, 6H); MS (ES+) m/z 399.1 (M+1).

Provenance & Evidence