反应详情

To a solution of 2-fluoro-4-iodotoluene (2.83 g, 12 mmol) in CCl4 (120 mL) were added NBS (2.24 g, 12.6 mmol) and BPO (0.06 g, 0.24 mmol). The reaction mixture was refluxed for 9 h under N2, then cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE) to give the title compound as a white solid (2.16 g, 57%).

1. temperatureThe reaction mixture was refluxed for 9 h under N2
2. concentrationconcentrated in vacuo
3. customThe residue was purified by a silica gel column chromatography (PE)