Methyl 2-((3-(5-(benzylcarbamoyl)-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoate → 2-((3-(5-(Benzylcarbamoyl)-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoic acid

Participants

Reaction Steps

Following the procedure as described in Example 25, making variations as required to replace ethyl 3-((3-(5-(benzylcarbamoyl)-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoate with methyl 2-((3-(5-(benzylcarbamoyl)-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoate, the title compound was obtained as a colorless solid in 76% yield: mp 153-156° C. (methanol/hexanes); 1H NMR (300 MHz, DMSO-d6) δ 8.49 (t, J=6.0 Hz, 1H), 7.86 (d, J=9.0 Hz, 1H), 7.57-7.51 (m, 1H), 7.40-7.19 (m, 7H), 4.78 (s, 2H), 4.34 (d, J=6.0 Hz, 2H), 4.01 (t, J=9.0 Hz, 2H), 3.50 (t, J=9.0 Hz, 2H), 2.46 (s, 3H); MS (ES+) m/z 451.2 (M+1).

Provenance & Evidence