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4-(2-Fluoro-4-nitrobenzyl)morpholine → 3-Fluoro-4-morpholin-4-ylmethylphenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(2-Fluoro-4-nitrobenzyl)morpholine | HCID 21955027 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Fluoro-4-morpholin-4-ylmethylphenylamine | HCID 21955013 | — |
反応手順
To a solution of 4-(2-fluoro-4-nitrobenzyl)morpholine (14.80 g, 62 mmol) in MeOH (100 mL) was added Pd/C (4.0 g). The reaction mixture was stirred at rt under H2 overnight and filtered. The filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a claybank solid (11.27 g, 87%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434695B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-0d576ea423314e0bb7f56e22029f8cce |
| 出典メモ | uspto-grants-2016_09 |