1-(Pyridazin-3-yl)methanamine → HCID 59481276, compound

Participants

Reaction Steps

Following the procedure as described in Example 32, making variations as required to replace 2-(3-((5-chlorobenzo[b]thiophen-3-yl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid to react with pyridazin-3-ylmethanamine, the title compound was obtained as a colorless solid in 52% yield: mp 222-225° C. (dichloromethane/hexanes); 1H NMR (300 MHz, DMSO-d6) δ 9.15 (dd, J=4.8, 1.6 Hz, 1H), 8.67 (t, J=5.7 Hz, 1H), 7.71-7.66 (m, 1H), 7.62-7.59 (m, 1H), 7.40-7.35 (m, 2H), 7.24-7.18 (m, 2H), 4.69 (d, J=5.7 Hz, 2H), 4.44 (s, 2H), 4.05-4.00 (m, 2 H), 3.50-3.45 (m, 2H), 2.50 (s, 3H); MS (ES+) m/z 427.2 (M+1).

Provenance & Evidence