Hydrazine hydrate (1:1) → HCID 178485432, compound

Participants

Reaction Steps

Following the procedure as described in Example 40, making variations as required to replace 1-(5-acetyl-4-methylthiazol-2-yl)-3-(4-(piperidine-1-carbonyl)benzyl)imidazolidin-2-one with 4-((3-(5-acetyl-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)-N-methylbenzamide to react with N,N-dimethylacetamide dimethyl acetal and further with hydrazine monohydrate, the title compound was obtained as a colorless solid in 80% yield: mp 236-238° C. (ethyl acetate); 1H NMR (300 MHz, DMSO-d6) δ 8.40 (d, J=4.2 Hz, 1H), 7.79 (d, J=8.1 Hz, 2H), 7.35 (d, J=8.1 Hz, 2H), 6.16 (s, 1H), 4.44 (s, 2H), 4.03-3.93 (m, 2H), 3.45-3.40 (m, 2H), 2.67 (d, J=4.2 Hz, 3H), 2.34 (s, 3H), 2.22 (s, 3H): 13C NMR (75 MHz, DMSO-d6) δ 166.7, 155.8, 144.0, 142.3, 140.1, 134.1, 128.0, 127.8, 102.7, 102.6, 47.1, 42.4, 42.3, 42.2, 26.7, 16.9.: MS (ES+) m/z 411.1 (M+1).

Provenance & Evidence