反应详情

To a solution of 2-(4-ethoxyphenyl)thiazole (1.03 g, 5.00 mmol) in DCM (30 mL) were added NBS (0.98 g, 5.50 mmol) and acetic acid (0.3 mL) with stirring at rt under N2. The reaction was stirred at 48° C. for 3 h, then cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (1.34 g, 94%).

1. stirringThe reaction was stirred at 48° C. for 3 h
2. temperaturecooled to rt
3. concentrationconcentrated in vacuo
4. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)