Ethyl 3-methyl-5-(2-oxo-3-(2-oxo-2-phenylethyl)imidazolidin-1-yl)thiophene-2-carboxylate → 3-Methyl-5-(2-oxo-3-(2-oxo-2-phenylethyl)imidazolidin-1-yl)thiophene-2-carboxylic acid

Participants

Reaction Steps

Following the procedure as described in Example 54, making variations as required to replace ethyl 3-methyl-5-(2-oxo-3-(2-phenoxyethyl)imidazolidin-1-yl)-thiophene-2-carboxylate with ethyl 3-methyl-5-(2-oxo-3-(2-oxo-2-phenylethyl)-imidazolidin-1-yl)thiophene-2-carboxylate, the title compound was obtained as a yellow solid in 58% yield: 1H NMR (300 MHz, DMSO-d6) δ 12.36 (br s, 1H), 8.02 (d, J=7.3 Hz, 2H), 7.74-7.67 (m, 1H), 7.61-7.54 (m, 2H), 6.34 (s, 1H), 4.85 (s, 2H), 3.97-3.88 (m, 2H), 3.67-3.58 (m, 2H), 2.41 (s, 3H); MS (ES+) m/z 345.3 (M+1).

Provenance & Evidence