Ethyl 5-(3-(4-(tert-butoxycarbonylamino)benzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylate → 5-(3-(4-(Tert-butoxycarbonylamino)benzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylic acid

Participants

Reaction Steps

Following the procedure as described in Example 54, making variations as required to replace ethyl 3-methyl-5-(2-oxo-3-(2-phenoxyethyl)imidazolidin-1-yl)-thiophene-2-carboxylate with ethyl 5-(3-(4-(tert-butoxycarbonylamino)benzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylate, the title compound was obtained as a pinkish solid in 64% yield: 1H NMR (300 MHz, DMSO-d6) δ 9.35 (br s, 1H), 7.43 (d, J=8.4 Hz, 2H), 7.17 (d, J=8.4 Hz, 2H), 6.27 (s, 1H), 4.31 (s, 2H), 3.85-3.76 (m, 2H), 3.45-3.36 (m, 2H), 2.39 (5, 3H), 1.46 (5, 9H); MS (ES−) m/z 430.4 (M−1).

Provenance & Evidence