4-(2-Fluoro-4-nitrophenyl)morpholine → 3-Fluoro-4-morpholinoaniline

Participants

Reaction Steps

To a solution of 4-(2-fluoro-4-nitrophenyl)morpholine (15.0 g, 66 mmol) in THF (100 mL) was added Pd/C (3.0 g). The reaction mixture was stirred at rt under H2 for 12 h. The mixture was filtered through a celite pad, and the filtrate was concentrated in vacuo to give the title compound as a white solid (11.55 g, 89%).

Provenance & Evidence