Oxazol-2-ylmethanamine → HCID 59481288, compound

Participants

Reaction Steps

Following the procedures as described in Example 55, making variations as required to replace 3-methyl-5-(2-oxo-3-(2-phenoxyethyl)imidazolidin-1-yl)thiophene-2-carboxylic acid with 5-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylic acid to react with oxazol-2-ylmethanamine, the title compound was obtained as a colorless solid in 35% yield: 1H NMR (300 MHz, CDCl3) δ 7.63 (s, 1H), 7.31-7.24 (m, 2H), 7.09-7.00 (m, 3H), 6.34 (t, J=5.0 Hz, 1H), 6.12 (s, 1H), 4.71 (d, J=5.0 Hz, 2H), 4.44 (s, 2H), 3.84-3.76 (m, 2H), 3.47-3.40 (m, 2H), 2.50 (s, 3H); MS (ES+) m/z 437.1 (M+23).

Provenance & Evidence