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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 560942Generated: October 31, 2026

Phenylboronic Acid → 2-Cyano-3-fluorobiphenyl

https://huagongshe.com/reaction/560942

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenylboronic AcidHCID 66827—
Reactant2-Fluoro-6-iodobenzonitrileHCID 522722—
ReactantEthanol toluene waterHCID 86587398—
SolventWater 1,2-dimethoxyethaneHCID 18180031—
Product2-Cyano-3-fluorobiphenylHCID 23509652—

Reaction Steps

The desired product was prepared by substituting 2-fluoro-6-iodobenzonitrile for Example 1A and phenylboronic acid for Example 1B in Example 1C. Additionally, toluene/EtOH/H2O (3:2:1) was substituted for DME/H2O as the solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08063091B2
Source datasetuspto-grants-2011_11
ORD IDord-b4a4b2eac9ae4f8db7ff85b56188b2c1
Source noteuspto-grants-2011_11