HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Fluoro-4-nitrophenyl)thiomorpholine → 3-Fluoro-4-thiomorpholinoaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Fluoro-4-nitrophenyl)thiomorpholine | HCID 10824071 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Fluoro-4-thiomorpholinoaniline | HCID 10822443 | — |
Reaction Steps
To a solution of 4-(2-fluoro-4-nitrophenyl)thiomorpholine (4.00 g, 16.51 mmol) in THF (50 mL) was added Pd/C (1.30 g). The reaction mixture was stirred at rt under H2 for 12 h. The mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound as an offwhite solid (3.40 g, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434695B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-d82ea57934c846269fb2f4566f349e94 |
| Source note | uspto-grants-2016_09 |