Acetic Anhydride → GlyTouCan:G72770YD

HRID 560959Notes

Reaction equation

HRID 560959 reaction equation
[N:1]([C@H:4]1[C@@H:17]([OH:18])[C@H:16]([F:19])[C@@H:15]([CH2:20][OH:21])[O:14][C@H:5]1[O:6]CC1C=CC=CC=1)=[N+]=[N-].[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[C:22]([NH:1][C@H:4]1[C@@H:17]([OH:18])[C@H:16]([F:19])[C@@H:15]([CH2:20][OH:21])[O:14][CH:5]1[OH:6])(=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 86600946benzyl 2-azido-2,4-dideoxy-4-fluoro-beta-D-mannopyranoside

Product 1

HCID 86600945GlyTouCan:G72770YD

Procedure

The present invention provides a process for preparing 5-acetamido-3,5,7-trideoxy-7-fluoro-D-glycero-β-D-lacto-2-nonulopyranosidonic acid comprising hydrogenating benzyl 2-azido-2,4-dideoxy-4-fluoro-β-D-mannopyranoside in the presence of acetic anhydride to obtain N-acetyl-4-deoxy-4-fluoro-D-mannosamine, and subsequently reacting the product with sodium piruvate, bovine serum albumin and aldolase sialate.

Workup

  1. customThe present invention provides a process
  2. customfor preparing 5-acetamido-3,5,7-trideoxy-7-fluoro-D-glycero-β-D-lacto-2-nonulopyranosidonic acid

Sources & evidence

ORD record
ord-4574dcf4046e48a1ba9a1b11d7df7a3b
Source dataset
uspto-grants-2011_11
Patent number
US08063202B2

Reaction notes

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