Potassium Carbonate → 4-(2-Fluoro-4-nitrophenyl)-1lambda~6~,4-thiazinane-1,1-dione

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1,2-Difluoro-4-nitrobenzene	HCID 123053	—
Reactant	Thiomorpholine 1,1-dioxide hydrochloride	HCID 12324096	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Solvent	Water	HCID 962	—
Product	4-(2-Fluoro-4-nitrophenyl)-1lambda~6~,4-thiazinane-1,1-dione	HCID 15984369	110.1%

Reaction Conditions

Temperature	100 °C

Reaction Steps

To a suspension of K2CO3 (5.53 g, 40 mmol) and 1,1-dioxo-thio-morpholinehydrochloride (3.60 g, 21 mmol) in DMSO (50 mL) was added 3,4-difluoronitrobenzene (3.18 g, 20 mmol). The reaction was heated at 100° C. for 12 h. The mixture was diluted with water (150 mL) and extracted with CH2Cl2 (100 mL×2). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid (6.04 g, 70%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09434695B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-99e1f1d0b8b147e5b818e5bd1574fa0a
Source note	uspto-grants-2016_09