反应详情

温度

2.5 °C

A mixture of 3-(4-methyl-benzenesulfonyl)-quinolin-4-ol (0.24 g, 0.8 mmol) and phosphorus(V) oxychloride (15 ml) was refluxed for 5 hours. Phosphorus(V) oxychloride was distilled off, and the residue was poured onto ice. The slurry was stirred for 2 hours at 0-5° C., neutralized with sodium carbonate and extracted with chloroform (50 ml). The organic layer was dried over anhydrous sodium sulfate, filtered and the solvent was removed in vacuo to give 0.23 g of the title compound in 90% yield.

1. temperaturewas refluxed for 5 hours
2. distillationPhosphorus(V) oxychloride was distilled off
3. additionthe residue was poured onto ice
4. extractionextracted with chloroform (50 ml)
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. filtrationfiltered
7. customthe solvent was removed in vacuo