Potassium Carbonate → HCID 25168520, compound

Participants

Reaction Steps

A mixture of 4-chloro-3-(4-methyl-benzenesulfonyl)-quinolin-4-ol (0.2 g, 0.67 mmol) and 4-chlorophenylboronic acid (0.16 g, 1.0 mmol) in 8 ml dioxane was stirred for 20 hours at 90° C. with potassium carbonate (0.5 g, 3.6 mmol) and tetrakis-(triphenylphosphin)palladium(0) (0.04 g, 0.035 mmol). After cooling the mixture was concentrated in vacuo. The crude residue was purified by column chromatography on silica gel (Kieselgel 60, eluent: chloroform) to obtain 0.21 g of the title compound in 80% yield.

Provenance & Evidence