3-Nitroaniline → HCID 178526461, compound

HRID 561047Notes

Reaction equation

CO[C:3](=O)[C:4]([S:9]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[CH:13]=1)(=[O:11])=[O:10])=[CH:5][O:6]CC.[N+:21]([C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][CH:30]=1)[NH2:27])([O-:23])=[O:22]>>[F:19][C:14]1[CH:13]=[C:12]([S:9]([C:4]2[CH:3]=[N:27][C:26]3[C:28]([C:5]=2[OH:6])=[CH:29][CH:30]=[C:24]([N+:21]([O-:23])=[O:22])[CH:25]=3)(=[O:10])=[O:11])[CH:17]=[CH:16][C:15]=1[F:18]

Participants

Reactant 2

HCID 74233-Nitroaniline

HCID 67000236HCID 67000236, compound

Product 1

HCID 178526461HCID 178526461, compound

Procedure

The title compound was prepared applying the procedure described in Example 4 from 2-(3,4-difluoro-benzenesulfonyl)-3-ethoxy-acrylic acid methyl ester (3.49 g, 11.4 mmol) and 3-nitroaniline (1.57 g, 11.4 mmol). The yield was 1.6 g (38.3%).

Sources & evidence

ORD record: ord-36ef226ed3d140d8b70b1062f807275f
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063220B2

Reaction notes

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