反应详情

Following the procedures of example 14, (S)-benzyl-2-(2-bromoacetyl)pyrrolidine-1-carboxylate (0.295 g, 0.90 mmol) and 2-amino-3-bromo-5-methylpyridine (0.1765 g, 0.94 mmol), produced the crude material which was adsorbed onto silica gel and purified by flash chromatography (12 g SiO2, 0-50% ethyl acetate in hexanes) to give (S)-benzyl-2-(8-bromo-6-methylimidazo[1,2-a]pyridin-2-yl)pyrrolidine-1-carboxylate (0.165 g, 0.40 mmol, 44%).

1. customproduced the crude material which
2. custompurified by flash chromatography (12 g SiO2, 0-50% ethyl acetate in hexanes)