反应详情

A solution of 6 (1.85 g, 5.7 mmol) in a mixture of AcOH—H2O—H2SO4 (8:6:1 v/v, 75 mL) was heated at reflux for 2 h. The reaction mixture was poured into ice water and adjusted to pH 4 with 1M NaOH solution. A precipitate formed and was collected by filtration, washed successively with water and ethanol and then dried to give 7 (1.3 g, 77%) as a light yellow solid.

1. temperaturewas heated
2. temperatureat reflux for 2 h
3. customA precipitate formed
4. filtrationwas collected by filtration
5. washwashed successively with water and ethanol
6. customdried