反应详情

A solution of 7 (270 mg, 0.91 mmol) and N-2-pyridinyl-1,2-ethanediamine (250 mg, 1.82 mmol) in DMSO (7 mL) was stirred at 80° C. for 1 h. The reaction mixture was cooled and freeze-dried overnight. The crude product was taken up in methanol (75 mL) and the resulting precipitate was removed by filtration, washed with cold methanol and dried to yield 8 (285 mg, 75%) as a yellow solid.

1. temperatureThe reaction mixture was cooled
2. customfreeze-dried overnight
3. customthe resulting precipitate was removed by filtration
4. washwashed with cold methanol
5. customdried