HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-cyclopentyl-6,7-difluoro-8-methoxy-5-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate → Ethyl 1-cyclopentyl-6,7-difluoro-8-methoxy-5-amino-1,4-dihydro-4-oxoquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-cyclopentyl-6,7-difluoro-8-methoxy-5-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate | HCID 59003055 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | N,N-dimethylformamide ethanol | HCID 19794673 | — |
| Product | Ethyl 1-cyclopentyl-6,7-difluoro-8-methoxy-5-amino-1,4-dihydro-4-oxoquinoline-3-carboxylate | HCID 66999743 | 91% |
Reaction Steps
A solution of 16 (6.0 g, 15 mmol) in EtOH-DMF (4:1, v/v, 250 mL) was hydrogenated under atmospheric pressure over 10% Pd/C (600 mg) at room temperature overnight. The catalyst was removed by filtration over Celite and the filtrate was concentrated in vacuo to dryness to yield 17 (5.0 g, 90%) which was used crude in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063221B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-6b90a713d00e4fb5b729b63a6866d860 |
| Source note | uspto-grants-2011_11 |