反应详情

温度

0 °C

To a mixture of N,N-diethyl-4-(thiazol-2-yl)aniline (1.39 g, 6.00 mmol) and concentrated sulfuric acid (10 mL) was added concentrated nitric acid (0.45 mL) at −10° C. The reaction mixture was stirred at 0° C. for 3 h, then poured into ice water and extracted with CH2Cl2 (30 mL×3). The organic phase was dried over Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/CH2Cl2 (V/V)=1:1) to give the title compound as a yellow solid (0.73 g, 44%).

1. extractionextracted with CH2Cl2 (30 mL×3)
2. dry with materialThe organic phase was dried over Na2SO4
3. concentrationconcentrated in vacuo
4. customThe residue was purified by a silica gel column chromatography (PE/CH2Cl2 (V/V)=1:1)