HCID 59002835, compound → HCID 59002994, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-5-(N-methyltrifluoroacetamido)-4-oxoquinoline-3-carboxylate (880 mg, 2.03 mmol) in AcOH (10 mL), 6M HCl (5 mL) was added. The mixture was stirred at 100° C. for 4 h. After cooling, the solvent was removed by evaporation. 50 mL water was added, and the resulting precipitate was collected by filtration, washed with water and dried to give 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-5-methylamino-4-oxoquinoline-3-carboxylic acid (605 mg, 92%) as a yellow solid.

Provenance & Evidence