Water → HCID 59002883, compound

Participants

Reaction Steps

1 M aq. NaOH (1 mL) was added to a suspension of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-7-[2-(2-pyridylamino)ethylamino]-5-(trifluoroacetamido)quinoline-3-carbonitrile (100 mg, 0.198 mmol) in MeOH (5 mL). After stirring at room temperature for 8 h, water (10 mL) was added. The resulting precipitate was collected by filtration, washed with water and MeOH, and dried to give 5-amino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-7-[2-(2-pyridylamino)ethylamino]quinoline-3-carbonitrile (60.1 mg, 74%) as a pale brown solid.

Provenance & Evidence