N,N-diethyl-4-(5-nitrothiazol-2-yl)aniline → 2-(4-(Diethylamino)phenyl)thiazol-5-amine

Participants

Reaction Steps

To a solution of N,N-diethyl-4-(5-nitrothiazol-2-yl)aniline (0.73 g, 2.64 mmol) in MeOH (30 mL) was added Pd/C (73 mg). The reaction mixture was stirred at rt under H2 overnight, then filtered. The filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=5:1) to give the title compound as a white solid (0.45 g, 69%).

Provenance & Evidence