Water → HCID 59002877, compound

Participants

Reaction Steps

To a solution of ethyl (R)-5,6,7,8-tetrafluoro-1,4-dihydro-1-[(2-hydroxy-1-phenylethyl)amino]-4-oxo-3-quinolinecarboxylate (3.10 g, 7.57 mmol) in THF (60 mL) was added NaH (364 mg, 9.10 mmol, 60% in oil) and the mixture was stirred at room temperature for 10 h. The mixture was treated portionwise at 0° C. with water. A precipitate formed and was collected by filtration, washed successively with EtOAc and then dried to give ethyl(R)-8,9,10-trifluoro-2,3-dihydro-7-oxo-3-phenyl-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate (329 mg, 11%) as a solid.

Provenance & Evidence