Hydrochloric Acid → HCID 59003030, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of ethyl (R)-8,9-difluoro-2,3-dihydro-7-oxo-3-phenyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate (627 mg, 1.24 mmol) in EtOH (8 mL) was added 2M aq. NaOH (6.20 mL, 12.4 mmol) at room temperature and the mixture was heated at 50° C. for 3 h. The reaction mixture was added 2N HCl (11.4 mL) and water. A precipitate formed and was collected by filtration, washed successively with water and then dried to give (R)-8,9-difluoro-2,3-dihydro-7-oxo-3-phenyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (452 mg, 75%) as a yellow solid.

Provenance & Evidence