4-Methoxybenzylamine → HCID 59002991, compound

Participants

Reaction Steps

A solution of (R)-8,9-difluoro-2,3-dihydro-7-oxo-3-phenyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (432 mg, 0.903 mmol) and 4-methoxybenzylamine (400 μL, 4.51 mmol) in DMSO (4 mL) was stirred at 150° C. for 2 h. The reaction mixture was added portionwise at 0° C. with ice-water and the resulting precipitate was combined by filtration, washed with water. The cake washed with EtOH and collected by filtration and then dried to give (R)-9-fluoro-2,3-dihydro-8-(4-methoxybenzylamino)-7-oxo-3-phenyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (411 mg, 78%) as a pale yellow solid.

Provenance & Evidence