4-Methoxybenzylamine → HCID 59002955, compound

Participants

Reaction Steps

A solution of (S)-8,9-difluoro-2,3-dihydro-7-oxo-3-phenyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (560 mg, 1.15 mmol) and 4-methoxybenzylamine (520 μL, 5.86 mmol) in DMSO (5 mL) was stirred at 150° C. for 2 h. The reaction mixture was added portionwise at 0° C. to ice-water and the resulting precipitate was combined by filtration, washed with water. The cake washed with EtOH, collected by filtration and then dried to give (S)-9-fluoro-2,3-dihydro-8-(4-methoxybenzylamino)-7-oxo-3-phenyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (390 mg, 57%) as a pale yellow solid.

Provenance & Evidence