Trifluoroacetic acid → HCID 59002962, compound

Participants

Reaction Steps

A solution of ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-5-(4-methoxybenzylamino)-4-oxo-7-[2-(2-pyridylamino)ethylamino]quinoline-2-carboxylate (577 mg, 1.02 mmol) in CH2Cl2 (10 mL) was cooled to 0° C. and treated dropwise with trifluoroacetic acid (2 mL). The reaction mixture was stirred at room temperature for over night. The reaction mixture was diluted with CH2Cl2 and washed with saturated NaHCO3, brine, and dried over anhyd Na2SO4 followed by the removal of CH2Cl2. The crude product was purified by column chromatography (Hexane:EtOAc 1:1) to yield ethyl 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-[2-(2-pyridylamino)ethylamino]quinoline-2-carboxylate (336 mg, 74%) as a orange amorphous solid.

Provenance & Evidence